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After Saturdays opponent Tyrone Spong returned an doping test, oleksandr Usyks first bout at the research division is in jeopardy, states promoter Eddie Hearn.
32, usyk, amassed all four world titles at cruiserweight and his move up a branch has been anticipated.
But Surinamese-Dutch fighter Spongs position is in doubt after Voluntary Anti-Doping Association (Vada) testing.
We have reserve competitions standing by, tweeted Hearn.
Weve been approached by Vada to notify us that there has been a negative finding in Tyrone Spongs evaluation. Its been sent into the State of Illinois commission
Hearn said there will be an update on Tuesday.
Usyk is scheduled to confront Spong in Chicagos Wintrust Arena within his first departure since stopping Britains Tony Bellew in November, when he defended all four world cruiserweight names.
Spong competed in kickboxing before winning his first 14 struggles as a boxer and spent much of his combat career in martial arts.
Vada needs promoters or fighters to cover testing for the length of a fight build-up and works in MMA and boxing. It said Spong was part of its testing programme on 20 September.
Even the Las Vegas-based Vada has earned a reputation in boxing and was accountable for evaluations which resulted in the likes of heavyweight Jarrell Miller along with Mexicos SaulCanelo Alvarez facing bans.
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