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Oleksandr Usyk bout in the division is in jeopardy after a negative doping test was returned by Saturdays opponent Tyrone Spong, states promoter Eddie Hearn.
Usyk, 32, gathered all of four world titles at his move and cruiserweight up a division has been highly anticipated.
But Surinamese-Dutch fighter Spongs position is in doubt following Voluntary Anti-Doping Association (Vada) testing.
Weve book opponents standing by, tweeted Hearn.
Weve been approached by Vada to notify us that there has been a negative finding in Tyrone Spongs test. It has been delivered to the State of Illinois commission.
Hearn said there will be an upgrade on Tuesday.
When he defended all of four world cruiserweight titles usyk is scheduled to face Spong in the Wintrust Arena of Chicago since stopping Britains Tony Bellew in November.
Spong, 34, spent a lot of his combat career and competed before winning his first 14 struggles as a fighter in kickboxing.
Vada needs fighters or promoters to cover testing for the duration of a struggle build-up and functions in MMA and boxing. It stated Spong was a part of its testing programme in 20 September.
The Las Vegas-based Vada has earned a glowing reputation in boxing and has been responsible for tests which caused the likes of heavyweight Jarrell Miller and Mexicos SaulCanelo Alvarez.
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